epinephrine is a sympathomimetic agent, therefore, it increases the heart rate.
adelfa contains oleandrin which is a cardiac glycoside. glycosides are used in congestive heart failure. they inhibit the Na-K-ATPase pump, resulting to increased intracellular Na, and consequently, increased intracellular Ca. this results to enhanced myocardial contractility. glycosides in short, produce positive inotropy and negative chronotropy.
chronotropy = heart rate.
administration of epinephrine didn't produce a significant change in the cardiac activity of the turtle. administration of adelfa increased the heart rate, and decreased the force of contraction.
???
effect of adelfa containing glycosides -> positive inotropy, negative chronotropy
experimental result of adelfa administration -> negative inotropy, positive chronotropy
old trans -> adelfa is more effective than epinephrine in increasing heart rate and contractility
old trans = discussed in class last year = correct.
our present result = opposite of expected = because ???????????????????????
can't understand?
toxic?
i've been figuring this out since yesterday morning.
i started the powerpoint yesterday. i still haven't finished it.
my hypothesis: the dose of the adelfa was toxic.
sana si Dr. Tan ang facilitator tom sa labcon. para pwede sindakin. hehe
wish me luck.
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